Fostemsavir (BMS-663068) is an experimental prodrug developed by Bristol-Meyers Squibb for the treatment of HIV. by blocking the entry of the virus into healthy cells. This editorial by Phil Baran of The Scripps Research Institute reviews 15 years, 9 publications, and countless person-hours towards the development of this medication. This saga represents a stepwise refinement of the initial route towards a more commercial-friendly production with several methods now included in modern synthetic textbooks. These refined routes enabled the production of over a metric ton of compound for medical research. |
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December 2021
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